Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand.

PMID: 207271432010

Key Findings

Some mutations were not associated with resistance and could lead to misinterpretation of the genotypic methods.

0gene entries

23mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	T142M	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	I31S	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	H71D	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G122S	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	A146T	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	S104R	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	I31T	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	L35P	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	C72Y	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V125F	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	T174I	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V45A	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G74R	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	E127*	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	L19R	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	A46S	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G97S	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	V139G	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	L27P	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	S67P	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	-	A-11C	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	-	A-11G	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-