Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failure.

PMID: 213434462011

Key Findings

The study identified a point mutation (S337L) in the mprF gene, which encodes lysyl phosphatidylglycerol transferase, as a mechanism of daptomycin resistance in Staphylococcus aureus.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mprF	1	lysyl phosphatidylglycerol transferase	Daptomycin	Staphylococcus aureus	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mprF	S337L	-	increased lysinylation activity	Staphylococcus aureus	Daptomycin	Reslit	-

Browse Papers

Comparative genome sequencing of an isogenic pair of USA800 clinical methicillin-resistant Staphylococcus aureus isolates obtained before and after daptomycin treatment failure.

AMR Genes

AMR Mutations