Emergence of quinolone resistance among extended-spectrum beta-lactamase-producing Enterobacteriaceae in the Central African Republic: genetic characterization.

PMID: 218674862011Central African Republic

Key Findings

The study identifies qnrA1 as a plasmid-borne quinolone resistance gene and a common gyrA mutation (Ser83Leu) as mechanisms of quinolone resistance in ESBL-producing Enterobacteriaceae in the Central African Republic.

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1gene entry

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
qnrA	1	plasmid-borne quinolone resistance gene	CiprofloxacinNorfloxacin	Escherichia coli Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83L	-	-	Escherichia coli, Klebsiella pneumoniae	Ciprofloxacin\|Nalidixic acid\|Norfloxacin	Reslit	-

Browse Papers

Emergence of quinolone resistance among extended-spectrum beta-lactamase-producing Enterobacteriaceae in the Central African Republic: genetic characterization.

AMR Genes

AMR Mutations