Extending the Definition of the GyrB Quinolone Resistance-Determining Region in Mycobacterium tuberculosis DNA Gyrase for Assessing Fluoroquinolone Resistance in M. tuberculosis.

PMID: 222909422012

Key Findings

All mutations were experimentally validated and shown to confer fluoroquinolone resistance.

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrB	T539P	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrB	E540V	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrB	D500A	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrB	N538T	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-