The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.

PMID: 222935382012

Key Findings

The G671V variant of MRP1 is associated with increased doxorubicin-induced cardiac toxicity due to reduced efflux of GS-HNE, leading to increased intracellular accumulation of doxorubicin and oxidative stress.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mrp1	1	multidrug resistance-associated protein 1	-	-	Reslit	-

Browse Papers

The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal.

AMR Genes