Circular permutation in the Ω-loop of TEM-1 beta-lactamase results in improved activity and altered substrate specificity.

PMID: 225364522012

Key Findings

The study identifies circularly permuted variants of TEM-1 beta-lactamase, CFX011 and CFX019, which confer increased resistance to cefotaxime but decreased resistance to other β-lactam antibiotics.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
bla	1	beta-lactamase	Cefotaxime	Escherichia coli	Reslit	-

Browse Papers

Circular permutation in the Ω-loop of TEM-1 beta-lactamase results in improved activity and altered substrate specificity.

AMR Genes