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Key Findings
Three cfr-like genes from the order Bacillales were identified and shown to confer resistance to PhLOPSa antibiotics by methylating 23S rRNA at A2503.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| cfr | 1 | methyltransferase | PhenicolLincosamideOxazolidinonePleuromutilinStreptogramin a |
| Reslit | - |
| clbA | 1 | 23S rRNA (adenine(2503)-C(8))-methyltransferase ClbA | STREPTOGRAMINMACROLIDELINCOSAMIDE |
| Card DatabaseReference Gene Catalog | - |
| clbB | 1 | 23S rRNA (adenine(2503)-C(8))-methyltransferase ClbB | STREPTOGRAMINMACROLIDELINCOSAMIDE |
| Card DatabaseReference Gene Catalog | - |
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