Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli.

PMID: 225598372012

Key Findings

Multiple mutations in mdtC reduce cloxacillin efflux activity.

0gene entries

25mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mdtC	D136C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	S657C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	I650C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	S660C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	S602C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	M608C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	R651C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	D696C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	M274C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	F598C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	V652C	-	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	A685C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G178C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G597C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G600C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G601C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G607C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtB	-	G610C	reduces cloxacillin efflux activity	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G653C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	G654C	-	Escherichia coli	Cloxacillin	Reslit	-
mdtC	-	T596C	-	Escherichia coli	Cloxacillin	Reslit	-