Twelve positions in a beta-lactamase that can expand its substrate spectrum with a single amino acid substitution.

PMID: 226294232012

Key Findings

The study identifies twelve amino acid positions in the beta-lactamase PenA of Burkholderia thailandensis that can expand its substrate spectrum with single amino acid substitutions, leading to ceftazidime resistance.

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1gene entry

20mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
penA	1	beta-lactamase	Ceftazidime	Burkholderia thailandensis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	C69F	-	-	Burkholderia thailandensis	Ceftazidime	Reslit	-
penA	N170G	-	-	Burkholderia thailandensis	Ceftazidime	Reslit	-
penA	D179G	-	-	Burkholderia thailandensis	Ceftazidime	Reslit

Browse Papers

Twelve positions in a beta-lactamase that can expand its substrate spectrum with a single amino acid substitution.

AMR Genes

AMR Mutations