A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains.

PMID: 229128812012

Key Findings

A point mutation in the cycA gene of Mycobacterium bovis BCG, resulting in a G122S amino acid substitution, partially contributes to D-cycloserine resistance. The mutation affects the transporter's function, reducing D-cycloserine uptake and contributing to resistance.

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1gene entry

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
cycA	1	D-serine, L- and D-alanine, and glycine transporter	D-cycloserine	Mycobacterium bovis BCG Mycobacterium tuberculosis Mycobacterium smegmatis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
cycA	G122S	-	-	Mycobacterium bovis, Mycobacterium tuberculosis, Mycobacterium smegmatis	D-cycloserine	Reslit	-

Browse Papers

A point mutation in cycA partially contributes to the D-cycloserine resistance trait of Mycobacterium bovis BCG vaccine strains.

AMR Genes

AMR Mutations