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Key Findings
Mutations in the rpoB gene are responsible for rifampin resistance.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| H526D | - | disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule | Mycobacterium tuberculosis | Rifampin | Reslit | - | |
| H526L | - | disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule | Mycobacterium tuberculosis | Rifampin | Reslit | - | |
| H526G | - | disrupted the intermolecular hydrogen bond between wild-type His526 and the RIF molecule | Mycobacterium tuberculosis | Rifampin | Reslit | - | |
| H526R | - | had hydrogen bond contact with and electrostatic attraction to the RIF molecule | Mycobacterium tuberculosis | Rifampin | Reslit | - | |
| L533P | - | did not significantly change the intermolecular interaction between RpoB and RIF | Mycobacterium tuberculosis | Rifampin | Reslit | - | |
| S531L | - | disrupted the intermolecular hydrogen bond between wild-type Ser531 and the RIF molecule | Mycobacterium tuberculosis | Rifampin | Reslit | - |
© 2026 ResLit. Data sourced from PubMed literature analysis.
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