Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance.

PMID: 232361392012

Key Findings

The study identifies several mutations in the tetracycline resistance protein TetX2 that significantly enhance resistance to tetracycline, demonstrating that small changes in enzyme function can lead to substantial fitness advantages during adaptive evolution.

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1gene entry

7mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
tet(X2)	1	tetracycline resistance protein	Tetracycline	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
tet(X2)	T280A	-	-	E. coli	Tetracycline	Reslit	-
tet(X2)	T280S	-	-	E. coli	Tetracycline	Reslit	-
tet(X2)	N371I	-	-	E. coli	Tetracycline	Reslit

Browse Papers

Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance.

AMR Genes

AMR Mutations