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Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.

PMID: 232950592013

Key Findings

Mutations in gyrA are responsible for fluoroquinolone resistance.

0gene entries

8mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83Y	-	-	Klebsiella pneumoniae, Escherichia coli	Ciprofloxacin\|Levofloxacin	Reslit	-
gyrA	S83L	-	-	Klebsiella pneumoniae, Escherichia coli	Ciprofloxacin	Reslit	-
gyrA	S83F	-	-	Klebsiella pneumoniae, Escherichia coli	Ciprofloxacin	Reslit	-
gyrA	S83I	-	-	Escherichia coli, Klebsiella pneumoniae	Ciprofloxacin\|Levofloxacin	Reslit	-