Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.

PMID: 234594882013

Key Findings

The R182C mutation in amgS was shown to activate the AmgRS two-component system, leading to increased resistance to aminoglycosides.

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
amgS	R182C	-	gain-of-function mutation that activates the AmgRS two-component system, two-component system sensor histidine kinase AmgS	Pseudomonas aeruginosa	Tobramycin\|Gentamicin\|Amikacin\|Paromomycin\|Neomycin\|StreptomycinAMIKACIN/TOBRAMYCIN	ReslitReference Gene Catalog	-
amgS	V121G	-	two-component system sensor histidine kinase AmgS	Pseudomonas aeruginosa	AMIKACIN/TOBRAMYCIN	Reference Gene Catalog	-