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Key Findings
The study identifies mutations in the AdeRS two-component system that lead to overexpression of the AdeABC efflux pump, contributing to multidrug resistance in Acinetobacter baumannii.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| adeB | 1 | RND-type efflux pump component | TigecyclineAminoglycosideFluoroquinoloneChloramphenicolTrimethoprim |
| Reslit | - |
| adeR | 1 | two-component response regulator | - |
| Reslit | - |
| adeS | 1 | two-component sensor kinase |
| - |
|
Reslit |
| - |
| - |
| I252S | - | two-component sensor histidine kinase AdeS | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| E219A | - | efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| H189Y | - | two-component sensor histidine kinase AdeS | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| P56S | - | efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| L192R | - | efflux system response regulator transcription factor AdeR | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| N125K | - | two-component sensor histidine kinase AdeS | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| Q163Ter | - | two-component sensor histidine kinase AdeS | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
| G336S | - | two-component sensor histidine kinase AdeS | Acinetobacter baumannii | EFFLUX | Reference Gene Catalog | - |
© 2026 ResLit. Data sourced from PubMed literature analysis.
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