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Key Findings
The study identifies two novel IMP-type metallo-beta-lactamases, IMP-43 and IMP-44, which exhibit increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa isolates. IMP-43 has a Val67Phe substitution compared to IMP-7, while IMP-44 has Val67Phe and Phe87Ser substitutions compared to IMP-11. Both enzymes show enhanced catalytic efficiency against carbapenems.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| blaIMP | 2 | metallo-beta-lactamase | CarbapenemMEROPENEMERTAPENEMAMOXICILLINCEFOXITINIMIPENEMCEFIXIMECEFEPIMEAMPICILLIN+CLAVULANIC ACID+7 more |
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