Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15.

PMID: 253606332014China

Key Findings

The study characterized the KPC-15 variant, a carbapenemase with higher catalytic efficiency compared to KPC-2 for various beta-lactam antibiotics. Both KPC-15 and KPC-2 conferred resistance to multiple beta-lactam antibiotics, but KPC-15 showed improved efficiency in hydrolyzing certain substrates.

View on PubMed

8gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaKPC	3	carbapenemase	ImipenemMeropenemErtapenemCeftazidimeCefotaximeAztreonamAZTREONAMMEROPENEMTICARCILLIN+14 more	Klebsiella pneumoniae Escherichia coli J53Az R	Card DatabaseReference Gene CatalogResFinder Database

Browse Papers

Phenotypic and enzymatic comparative analysis of the KPC variants, KPC-2 and its recently discovered variant KPC-15.

AMR Genes