Detection of the SHV genotype polymorphism of the extended-spectrum beta-lactamase-producing Gram-negative bacterium.

PMID: 260750802015Chengdu, China

Key Findings

The study identified novel mutations in the blaSHV gene, including L35Q, I8F, R43S, G238S, G238A, and E240K, which contribute to resistance against various β-lactam antibiotics.

View on PubMed

6gene entries

12mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaSHV	3	beta-lactamase	CefoxitinCefotaximeCeftazidimeCeftriaxonePenicillinAmoxicillinOxacillinBETA-LACTAMUNKNOWN BETA-LACTAM	Escherichia coli Klebsiella pneumoniae	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaSHV	R43S	-	-	Escherichia coli, Klebsiella pneumoniae	Cefoxitin\|Cefotaxime\|Ceftazidime\|Ceftriaxone\|Penicillin\|Amoxicillin\|Oxacillin	Reslit	-
blaSHV	G238A	-	-	Klebsiella pneumoniae, Escherichia coli	Cefoxitin\|Cefotaxime\|Ceftazidime\|Ceftriaxone\|Penicillin\|Amoxicillin\|Oxacillin	Reslit	-
blaSHV	L35Q	-	-	Klebsiella pneumoniae, Escherichia coli

Browse Papers

Detection of the SHV genotype polymorphism of the extended-spectrum beta-lactamase-producing Gram-negative bacterium.

AMR Genes

AMR Mutations