Consensus numbering system for the rifampicin resistance-associated rpoB gene mutations in pathogenic mycobacteria.

PMID: 276647762017

Key Findings

Mutations in the rpoB gene are associated with rifampicin resistance in Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium kansasii.

0gene entries

9mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	H472R	A1417G	-	Mycobacterium kansasii, Mycobacterium tuberculosis, Mycobacterium leprae	Rifampicin	Reslit	-
rpoB	I491F	A1473T	-	Mycobacterium leprae, Mycobacterium kansasii, Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S450L	C1351T	-	Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium kansasii	Rifampicin	Reslit	-