An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.

PMID: 276707152016

Key Findings

The W73C mutation in the receiver domain of LiaR leads to constitutive activation and increased daptomycin resistance.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
liaR	W73C	-	constitutive activation	Enterococcus faecium	Daptomycin	Reslit	-