In Vivo Emergence of Resistance to Novel Cephalosporin–β-Lactamase Inhibitor Combinations through the Duplication of Amino Acid D149 from OXA-2 β-Lactamase (OXA-539) in Sequence Type 235 Pseudomonas aeruginosa.

PMID: 286740592017

Key Findings

The study identifies OXA-539, a novel beta-lactamase resulting from the duplication of amino acid D149 from OXA-2, which confers resistance to ceftazidime, ceftazidime-avibactam, and ceftolozane-tazobactam in Pseudomonas aeruginosa ST235.

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6gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaOXA	2	beta-lactamase	CeftazidimeCeftazidime-avibactamCEFTAZIDIME+AVIBACTAMCEPHALOSPORINAMOXICILLINCEFEPIMEAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFTAZIDIME+2 more	Pseudomonas aeruginosa ST235 Pseudomonas aeruginosa	Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Browse Papers

In Vivo Emergence of Resistance to Novel Cephalosporin–β-Lactamase Inhibitor Combinations through the Duplication of Amino Acid D149 from OXA-2 β-Lactamase (OXA-539) in Sequence Type 235 Pseudomonas aeruginosa.

AMR Genes