Role of AmpR in the High Expression of the Plasmid-Encoded AmpC beta-lactamase CFE-1.

PMID: 288086892017

Key Findings

The study identifies a point mutation in AmpR (Asp135Ala) that leads to constitutive high-level expression of the plasmid-encoded AmpC beta-lactamase CFE-1, resulting in high resistance to cephalosporins.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCFE	1	beta-lactamase	Cephalosporin	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ampR	D135A	-	activator	Escherichia coli	Cephalosporin	Reslit	-

Browse Papers

Role of AmpR in the High Expression of the Plasmid-Encoded AmpC beta-lactamase CFE-1.

AMR Genes

AMR Mutations