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Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan.

PMID: 288177232017

Key Findings

mutations in rpoB gene associated with rifampicin resistance

0gene entries

13mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	D516G	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D516A	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H526Y	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S531C	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D516V	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S531W	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	L533P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S531L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H526G	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S531A	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D516Y	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H526P	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H526Q	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-