The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor.

PMID: 288982932017

Key Findings

The study identified VarG as a metallo-β-lactamase capable of hydrolyzing various β-lactam antibiotics, including carbapenems, and VarABCDEF as an antibiotic efflux pump that confers resistance to macrolides. These genes are regulated by VarR, a LysR-type transcription factor.

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2gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
varG	1	metallo-beta-lactamase	PenicillinCephalosporinCarbapenemCARBAPENEM	Vibrio cholerae Escherichia coli	Reference Gene CatalogReslit	-

Browse Papers

The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor.

AMR Genes