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Diversity of Mosaic pbp2x Families in Penicillin-Resistant Streptococcus pneumoniae from Iran and Romania.

PMID: 289718782017

Key Findings

Mutations in the transpeptidase domain of PBP2x were identified as contributing to penicillin and cefotaxime resistance.

0gene entries

32mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2x	I371T	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	N444S	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	N605T	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	T338A	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	S389L	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	L510T	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	T338P	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	Q405K	-	-	Streptococcus mitis, Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	L364F	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	N417K	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	T513N	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	A369V	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	A446G	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-
pbp2x	S531K	-	-	Streptococcus mitis, Streptococcus pneumoniae	Penicillin\|Cefotaxime	Reslit	-
pbp2x	Y595F	-	-	Streptococcus pneumoniae, Streptococcus mitis	Penicillin\|Cefotaxime	Reslit	-