Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection.

PMID: 318606672019

Key Findings

The F198L mutation in NalD was shown to confer aztreonam resistance by derepressing the mexAB-oprM efflux system.

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
nalD	F198L	-	loss of function, efflux system transcriptional repressor NalD	Pseudomonas aeruginosa	AztreonamAZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM	ReslitReference Gene Catalog	-