Detection of mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains inhibiting wild type probe hybridization in the MTBDR plus assay by DNA sequencing directly from clinical specimens.

PMID: 329383932020

Key Findings

Mutations in the rpoB gene associated with rifampicin resistance

0gene entries

26mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	S531L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	H526Y	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	D516V	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	A514C	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	A514T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	A515C	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	A517T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	A518G	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	A527T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	C508A	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	C512G	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	C513G	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	C526A	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	C526T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	C528T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	CAA-GTA	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	CAC-TGC	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	G516T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	G534T	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	T512C	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	TCG-TAT	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	TCG-TGC	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	TCG-TTC	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	-	TCG-TTT	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-