Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.

PMID: 334684632021

Key Findings

The study identifies the IMP-78 variant (S262G/V67F) as having the largest changes in MIC values compared to IMP-1, indicating its enhanced resistance to carbapenems. Mutations S262G and V67F in IMP-1-like variants increase resistance to carbapenems but decrease resistance to ampicillin.

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2gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaIMP	2	metallo-beta-lactamase	CarbapenemMeropenemImipenemErtapenemAmpicillinCeftazidimeCephalothin	Escherichia coli Pseudomonas aeruginosa	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaIMP	V67F	-	-	E. coli	Carbapenem	Reslit	-
blaIMP	S262G	-	-	E. coli	Carbapenem	Reslit	-

Browse Papers

Carbapenem Use Is Driving the Evolution of Imipenemase 1 Variants.

AMR Genes

AMR Mutations