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Key Findings
Mutations P45L, P45S, I480V, V534M, and R827L are compensatory mutations that improve the fitness of the S450L mutant.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| S450L | - | confers rifampicin resistance | Mycobacterium smegmatis | Rifampicin | Reslit | - | |
| V170F | - | confers rifampicin resistance | Mycobacterium smegmatis | Rifampicin | Reslit | - | |
| I491F | - | confers rifampicin resistance | Mycobacterium smegmatis | Rifampicin | Reslit | - |
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