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Key Findings
The study identifies specific mutations in the ermS gene that affect erythromycin resistance, highlighting the role of amino acid residues S64, Q65, and F67 in the resistance mechanism.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| erm(S) | 1 | rRNA methyltransferase | Erythromycin |
| Reslit | - |
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| S64G | - | S64G exhibited 71% activity compared to the wild-type | Escherichia coli | Erythromycin | Reslit | - | |
| Q65H | - | Q65H lost methyl group transferring activity | Escherichia coli | Erythromycin | Reslit | - | |
| S64C | - | S64C exhibited 20% activity compared to the wild-type | Escherichia coli | Erythromycin |
| - |
| F67H | - | F67H reduced activity to about 4% | Escherichia coli | Erythromycin | Reslit | - |
| Q65N | - | Q65N lost methyl group transferring activity | Escherichia coli | Erythromycin | Reslit | - |
| F67L | - | F67L caused a moderate loss of activity | Escherichia coli | Erythromycin | Reslit | - |
| Q65E | - | Q65E lost methyl group transferring activity | Escherichia coli | Erythromycin | Reslit | - |
| F67W | - | F67W reduced activity by about 75% | Escherichia coli | Erythromycin | Reslit | - |
| Q65R | - | Q65R lost methyl group transferring activity | Escherichia coli | Erythromycin | Reslit | - |
| F67Y | - | F67Y reduced activity by about 75% | Escherichia coli | Erythromycin | Reslit | - |
| S64A | - | S64A exhibited 21% activity compared to the wild-type | Escherichia coli | Erythromycin | Reslit | - |
| F67A | - | F67A reduced activity to about 4% | Escherichia coli | Erythromycin | Reslit | - |
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