Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis.

PMID: 338329722021

Key Findings

Mutations in kupB and glnPQ restore cefuroxime resistance in cdiA mutants of Lactococcus lactis by reducing intracellular osmolyte levels.

1gene entry

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
glnpq	1	Amino acid ATP-binding cassette transport system	Cefuroxime	Lactococcus lactis	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
glnPQ	G569W	-	-	Lactococcus lactis	Cefuroxime	Reslit	-
glnPQ	S621N	-	-	Lactococcus lactis	Cefuroxime	Reslit	-
glnPQ	H199Q	-	-	Lactococcus lactis	Cefuroxime	Reslit