Screening of Compounds for Anti-tuberculosis Activity, and in vitro and in vivo Evaluation of Potential Candidates.

PMID: 342765922021

Key Findings

The D94G mutation in gyrA was found to be the key role of resistance to orbifloxacin.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	D94G	-	disrupts the binding of orbifloxacin with protein GyrA	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-