Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium.

PMID: 342784322021

Key Findings

The study shows that AcrE can form a functional complex with AcrD, indicating interchangeability between AcrA and AcrE in forming efflux pumps. Mutations in specific residues of AcrA and AcrE impair AcrD-mediated efflux.

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3gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
acrA	1	periplasmic adaptor protein	AztreonamCarbenicillinCloxacillinFusidic acidNafcillinNovobiocinOxacillinTicarcillin	Salmonella enterica serovar Typhimurium	Reslit	-
acrD	1	RND transporter	AztreonamCarbenicillin

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
acrE	G362F	-	-	Salmonella enterica	Aztreonam\|Carbenicillin\|Cloxacillin\|Fusidic acid\|Nafcillin\|Novobiocin\|Oxacillin\|Ticarcillin	Reslit	-
acrA	G363F	-	-	Salmonella enterica	Aztreonam\|Carbenicillin\|Cloxacillin\|Fusidic acid\|Nafcillin\|Novobiocin\|Oxacillin\|Ticarcillin	Reslit	-

Browse Papers

Interchangeability of periplasmic adaptor proteins AcrA and AcrE in forming functional efflux pumps with AcrD in Salmonella enterica serovar Typhimurium.

AMR Genes

AMR Mutations