Lactococcus lactis Resistance to Aureocin A53- and Enterocin L50-Like Bacteriocins and Membrane-Targeting Peptide Antibiotics Relies on the YsaCB-KinG-LlrG Four-Component System.

PMID: 345162502021

Key Findings

The study identifies mutations in the YsaCB-KinG-LlrG system that confer resistance to Aureocin A53- and Enterocin L50-like bacteriocins and membrane-targeting antibiotics in Lactococcus lactis.

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2gene entries

8mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
ysaB	1	Permease subunit of the ABC transporter YsaCB	Daptomycin	Lactococcus lactis	Reslit	-
ysaC	1	ATPase subunit of the ABC transporter YsaCB	Daptomycin	Lactococcus lactis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ysaB	Q566X	-	-	Lactococcus lactis	Daptomycin\|Gramicidin	Reslit	-
ysaB	E190X	-	-	Lactococcus lactis	Daptomycin\|Gramicidin	Reslit	-
ysaB	E582X	-	-	Lactococcus lactis	Daptomycin\|Gramicidin	Reslit

Browse Papers

Lactococcus lactis Resistance to Aureocin A53- and Enterocin L50-Like Bacteriocins and Membrane-Targeting Peptide Antibiotics Relies on the YsaCB-KinG-LlrG Four-Component System.

AMR Genes

AMR Mutations