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Key Findings
Mutations in pncA are associated with pyrazinamide resistance.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| H51P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| H82P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| Q10P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| T135P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| Q141P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| T160A | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| M175V | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| A46E | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| A46V | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| - | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| A46T | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| D8N | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| I104S | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| E112K | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| D126N | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| E181K | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| W68R | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| V93G | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| L116P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| V128G | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| I133T | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| V155G | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | ||
| S164P | - | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - |
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