Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases.

PMID: 348433762022

Key Findings

The study identifies EptA and MCR-1 as crucial for polymyxin resistance by modifying lipid A with phosphoethanolamine. It shows that DAG accumulation inhibits EptA activity, reducing lipid A modification and polymyxin resistance.

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1gene entry

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mcr-1	1	phosphoethanolamine transferase	Colistin	Escherichia coli	Reslit	-

Browse Papers

Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases.

AMR Genes