Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis.

PMID: 351008712021

Key Findings

The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
sigE	V166L	-	The V166L substitution falls within the SigE σ 2 /σ 4 linker, influencing transcription initiation.	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-