Structural and Dynamic Insights into the W68L, L85P, and T87A Mutations of Mycobacterium tuberculosis Inducing Resistance to Pyrazinamide.

PMID: 351626362022

Key Findings

The W68L mutation in pncA was found to reduce the binding affinity of pyrazinamide (PZA) to the enzyme, leading to resistance.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	W68L	-	reduce the binding affinity of pyrazinamide (PZA) to the enzyme	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-