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A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from Mycobacterium tuberculosis.

PMID: 354241442021

Key Findings

Mutations in the pncA gene lead to reduced binding affinity of PZA to PZase, resulting in pyrazinamide resistance.

0gene entries

7mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	K96N	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	K96R	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	F94L	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G97D	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G97C	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	F94S	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	G97S	-	reduced binding affinity of PZA to PZase	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-