Key Findings

The study identifies multidrug efflux pumps MexAB-OprM, MexCD-OprJ, MexEF-OprN, and MexXY-OprM as the primary resistance determinants in Pseudomonas aeruginosa AUST-03 isolates. Mutations in regulatory genes mexR, mexT, nalC, and nfxB contribute to the upregulation of these efflux pumps. Additionally, the study detects several antibiotic resistance genes, including crpP, blaOXA-50, blaOXA-1034, blaPDC-3, and blaPDC-374, which are associated with resistance to various antibiotics.