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Adoption of an in-silico analysis approach to assess the functional and structural impacts of rpoB-encoded protein mutations on Chlamydia pneumoniae sensitivity to antibiotics.

PMID: 401027272025

Key Findings

All mutations were identified in previous studies and analyzed in-silico.

0gene entries

7mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	F450S	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-
rpoB	S454F	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-
rpoB	D461E	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-
rpoB	S476F	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-
rpoB	L478S	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-
rpoB	R421S	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-
rpoB	S519Y	-	-	Chlamydia pneumoniae	Rifampin\|Rifalazil	Reslit	-