Functional and structural analyses of amino acid sequence variation in PDC beta-lactamase reveal different mechanistic pathways toward cefiderocol resistance in Pseudomonas aeruginosa.

PMID: 404220842025

Key Findings

The study identifies E219K and L293P mutations in the PDC beta-lactamase that significantly enhance cefiderocol resistance in Pseudomonas aeruginosa through distinct enzymatic mechanisms.

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1gene entry

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaPDC	1	beta-lactamase	-	Pseudomonas aeruginosa	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaPDC	L293P	-	enhanced cefiderocol hydrolysis	Pseudomonas aeruginosa	Cefiderocol	Reslit	-
blaPDC	E219K	-	enhanced cefiderocol hydrolysis	Pseudomonas aeruginosa	Cefiderocol	Reslit	-

Browse Papers

Functional and structural analyses of amino acid sequence variation in PDC beta-lactamase reveal different mechanistic pathways toward cefiderocol resistance in Pseudomonas aeruginosa.

AMR Genes

AMR Mutations