Mutation- and Transcription-Driven Omic Burden of Daptomycin/Dalbavancin-R and Glycopeptide-RS Fitness Costs in High-Risk MRSA: A Nexus in Antimicrobial Resistance Mechanisms-Genome Proneness-Compensatory Adaptations.

PMID: 404265322025

Key Findings

The study identified a stop codon in the mprF gene, which contributes to daptomycin resistance in VISA DAP-R CA-MRSA superbugs.

1gene entry

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mprF	1	Phosphatidylglycerol L-lysyltransferase	Daptomycin	Staphylococcus aureus	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mprF	T345I	-	-	-	Daptomycin	Reslit	-
mprF	T345A	-	-	-	Daptomycin	Reslit	-
mprF	S295L	-	-	-	Daptomycin	Reslit	-