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Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin.

PMID: 404493262025

Key Findings

Mutations at codon 435 (D435G, D435V) conferred increased CAP tolerance, while mutations at codon 445 (H445Y, H445R) enhanced CAP bactericidal effect.

0gene entries

26mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	D435G	A1305G GAC->GGC	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	CAPCapreomycin	Reslit	-
rpoB	D435V	A1305T GAT->GTT	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	CAPCapreomycin	Reslit	-
rpoB	S441L	AGC->CTC	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	CapreomycinCAP	Reslit	-
rpoB	S441W	AGC->TGG	-	Mycobacterium tuberculosis, Mycobacterium smegmatis	CAP	Reslit	-
rpoB	H445R	CAC->CGT CAT->CGT	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	CAPCapreomycin	Reslit	-
rpoB	H445Y	CAC->TAT CAT->TAT	-	Mycobacterium smegmatis, Mycobacterium tuberculosis	CAPCapreomycin	Reslit	-
rpoB	S450L	TCA->CTA TCC->CTC	-	Mycobacterium tuberculosis, Mycobacterium smegmatis	CapreomycinCAP	Reslit	-