Key Findings

The study identified several genes and mutations associated with resistance to ceftazidime-avibactam (CZA) and meropenem (MEM) in Pseudomonas aeruginosa, including dacB, ftsI, oprD, mexB, mexR, and ampC. Mutations in these genes were linked to resistance mechanisms, and CRISPR-Cas9 experiments confirmed the role of certain mutations in altering resistance levels.