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Predicting rifampicin resistance in Mycobacterium tuberculosis using machine learning informed by protein structural and chemical features.

PMID: 405899032025

Key Findings

mutations in rpoB are associated with rifampicin resistance

0gene entries

6mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	L378R	CTT->AGG	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	L731P	CTT->CCC	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	E207K	GAG->AAA	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	V262A	GTT->GCA	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S582A	T1746G	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	S493R	TCA->CGA	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-