Catalytic Residue Reprogramming Enhances Enzyme Activity at Alkaline pH via Phenolate-Mediated Proton Transfer.

PMID: 408913402025

Key Findings

Mutations in the catalytic residue Glu166 affect pH-dependent activity

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaTEM	Y166E	-	-	E. coli	Ampicillin	Reslit	-
blaTEM	S170N	-	-	E. coli	Ampicillin	Reslit	-
blaTEM	I68M	-	-	E. coli	Ampicillin	Reslit	-
blaTEM	E166Y	-	-	E. coli	Ampicillin	Reslit	-