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In vitro exposure to clofazimine can select for delamanid and pretomanid resistance in Mycobacterium tuberculosis.

PMID: 409809172025

Key Findings

Mutations in Rv0678 confer resistance to clofazimine

3gene entries

4mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
fbiA	1	non-essential gene involved in activation of delamanid and pretomanid	DelamanidPretomanid	Mycobacterium tuberculosis	Reslit	-
fbiC	1	non-essential gene involved in activation of delamanid and pretomanid	DelamanidPretomanid	Mycobacterium tuberculosis	Reslit	-
Rv0678	1	negative regulator of the MmpS5-MmpL5 efflux pump	Clofazimine	Mycobacterium tuberculosis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Rv0678	214fs	-	-	Mycobacterium tuberculosis	Clofazimine	Reslit	-
Rv0678	172del	-	-	Mycobacterium tuberculosis	Clofazimine	Reslit	-
Rv0678	344fs	-	-	Mycobacterium tuberculosis	Clofazimine	Reslit