Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.

PMID: 409863432025

Key Findings

The study identifies MmpL5 mutations that increase bedaquiline efflux, suggesting potential resistance mechanisms beyond pump upregulation.

1gene entry

10mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mmpL5	1	efflux pump component	Bedaquiline	Mycobacterium tuberculosis Mycobacterium marinum	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mmpL5	N444K	-	increases bedaquiline efflux	Mycobacterium marinum, Mycobacterium tuberculosis	Bedaquiline	Reslit	-
mmpL5	V193D	-	increases bedaquiline efflux	Mycobacterium tuberculosis, Mycobacterium marinum	Bedaquiline	Reslit	-
mmpL5	Q196M	-	increases bedaquiline efflux	Mycobacterium marinum, Mycobacterium tuberculosis	Bedaquiline