Unveiling meropenem resistance and co-resistance patterns in Klebsiella pneumoniae and Acinetobacter baumannii: a global genome analysis using ML/DL and association mining.

PMID: 411628932025USA

Key Findings

The study identified key AMR genes and mutations associated with meropenem resistance in Klebsiella pneumoniae and Acinetobacter baumannii, including bla KPC−2, bla KPC−3, ble MBL, aac(6')-Ib9, bla OXA−23, and aac(6')-Ib7, as well as mutations in oqxA, kpnE, kpnG, tet(A), adeR, Abau_OprD_IPM, and Abau_gyrA_FLO.

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2gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
aac(6')	2	aminoglycoside N-acetyltransferase	Aminoglycoside	Klebsiella pneumoniae Acinetobacter baumannii	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
adeR	L142I	-	-	Acinetobacter baumannii	Meropenem	Reslit	-

Browse Papers

Unveiling meropenem resistance and co-resistance patterns in Klebsiella pneumoniae and Acinetobacter baumannii: a global genome analysis using ML/DL and association mining.

AMR Genes

AMR Mutations